by Garth Ennis (Author), Tim Bradstreet (Cover Art), Doug Braithwaite (Artist), Leandro Fernandez (Artist) 

Collects Punisher (2004) #13-30.

Nick Fury has a dangerous mission for the Punisher: break into a Siberian nuclear missile silo and steal a lethal retrovirus. But Castle soon sets off a chain reaction that will bring him into conflict with a ruthless Russian general — and take the world to the brink of war. Then, mobster Nicky Cavella returns to plague the Punisher. But when his scheme unleashes a wave of violence that rocks New York to its core, other predators emerge from the darkness. Finally, the Punisher targets a human-trafficking operation that supplies kidnapped girls to brothels. Veterans of Eastern Europe's ethnic genocide, the cruel slavers are a quarry unlike any Castle has hunted before. They're ready to go to war to protect what's theirs — but they'll soon find out exactly what war with the Punisher means.